국내 paclitaxel resistance a549
WebJan 2, 2024 · Farmakokinetik. Paclitaxel dilaporkan memiliki farmakokinetik nonlinear, terutama jika diberikan melebihi 3 jam. Konsentrasi plasma maksimum dan area under … WebA549 or paclitaxel-resistant A549 cells were seeded at 3000 cells/well in 96-well plates and cultured overnight. SphK1 specific inhibitor SKI-II, Cisplatin or paclitaxel were then added to the wells at varying concentrations. The cells were further cultured for additional 3 …
국내 paclitaxel resistance a549
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WebMay 15, 2024 · This study provides new insights into the molecular mechanism of DDP resistance in lung cancer, and downregulated miR-100–5p was proved to be involved in … WebThis study aimed to investigate the effect of apatinib on the reversal of paclitaxel (PTX) resistance in A549 lung cancer cells (A549/PTX) and related mechanisms. Materials …
WebCell culture and establishment of paclitaxel-resistant A549-Taxol The paclitaxel-resistant A549-Taxol cell line was estab-lished as previously reported. Briefly, the cell lines were … WebEstablishment of A549 paclitaxel-resistant cells in vivo. (a) A suspension of A549 cells was injected subcutaneously into the flank of a nude mouse. When the average tumor volume …
WebIn this work, we established paclitaxel-resistant cells (A549-T) from parental cell lines by step-dose selection in vitro. Using methylation chip analysis and transcriptome … WebMay 25, 2010 · The paclitaxel-resistant A549-Taxol cell line was established as previously reported. Briefly, the cell lines were selected to be paclitaxel resistant by continuous …
WebApr 1, 2024 · All four active compounds, with IC 50 values ranging from 0.002 to 0.91 μM, had better inhibitory activities against A549/Taxol cells than paclitaxel (IC 50 = 1.80 μM). Among them, cucurbitacin E (IC 50 = 0.002 μM) is the most active. Further studies are needed to evaluate their in vivo antitumor activities and to clarify their mechanisms.
WebAbstract Objective To investigate the effect of the SMAC gene on paclitaxel sensitivity and cellular activity in lung adenocarcinoma cells based on the caspase-3/Bcl-2/Bax signaling pathway. Methods A paclitaxel-resistant cell line A549/Taxol was established for lung adenocarcinoma, and the cells were divided into four following groups: pcDNA-NC … change photo dpiWebJun 9, 2024 · Figure 3 B showed that IC50 values for paclitaxel in A549 and A549/PA cells were 1.23 ± 0.14 and 7.03 ± 0.32 μmol/L, respectively, indicating much higher values for A549/PA cells, whose resistance index (RI) was 5.02. A549/PA cells showed more powerful resistance to paclitaxel ( P < 0.05). hardware system integrationWebHDAC activity and function in paclitaxel-resistant NSCLC cells. (a) The effect of paclitaxel on the cell viability of A549 and A549/T cells. The cells were treated with various... hardware system infoWebFeb 16, 2024 · The paclitaxel-resistant strain A549-T was established from the parental cell lines by step-dose selection in vitro over six months. We carried out single-cell … change photo extension onlineWebAnalysis of Differential Expression Proteins of Paclitaxel-Treated Lung Adenocarcinoma Cell A549 Using Tandem Mass Tag-Based Quantitative Proteomics. Background: Paclitaxel is widely used in the treatment of cancer and has a good effect in the treatment of non-small cell lung cancer. The combination of TMT proteomics and bioinformatics is used ... change photo dimensions iphoneWebThe combination of conventional cytotoxic drugs has been a plausible strategy for overcoming paclitaxel resistance. Herein, we investigated the cytotoxic effects and underlying mechanism of LSS-11, a novel naphthalimide derivative-based topoisomerase inhibitor, in paclitaxel-resistant A549 (A549/T) lung cancer cells. LSS-11 enhanced cell … hardware systems west palm beachWebMar 1, 2024 · Paclitaxel (PTX) is a common antineoplastic drug whose functionality is often restricted by drug resistance. Solute carrier organic anion transporter family member … hardware system requirements