Eif4a2
Web13682 Ensembl ENSG00000156976 ENSMUSG00000022884 UniProt Q14240 P10630 RefSeq (mRNA) NM_001967 NM_001123037 NM_001123038 NM_013506 … WebApr 1, 2024 · EIF4A2 gene silencing. pIECs were cultured in six-well culture plates and transfected with siRNAs (20 nM). The cell lysates were harvested for Western blotting at …
Eif4a2
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WebDec 25, 2024 · We identified eIF4A2 and defined its mechanistic action through Rps26-independent and -dependent ribosomes in translation initiation activation of mRNAs encoding pluripotency factors and the histone variant H3.3 with demonstrated roles in maintaining stem cell pluripotency. eIF4A2 also mediates translation initiation activation … WebThe eIF4A proteins are involved in many aspects of RNA metabolism due to their RNA-binding capacity and ATPase activity. eIF4A1 and eIF4A2 are cytoplasmic, whereas eIF4A3 is nuclear-localized. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient ...
WebDec 16, 2024 · 15 individuals with mono-allelic or inherited bi-allelic variants in the DEAD-box gene EIF4A2 were identified with global developmental delay, intellectual disability, hypotonia, epilepsy, and structural brain anomalies. In Drosophila melanogaster, mono-allelic variants in EIF4A2 led to variant-specific behavioral and developmental defects, … WebApr 1, 2024 · The EIF4A2 gene is located approximately 1 MB away from BCL6 on chromosome 3q27 in a tail-to-tail orientation ( Fig. 2 ), and this rearrangement is reportedly produced by a paracentric inversion which is cryptic to FISH analysis [39], as was also seen in the current report.
WebTarget Information eIF4A2 is a 407 amino acid ATP-dependent RNA helicase belonging to the DEAD box helicase family. It contains one helicase ATP-binding domain and a helicase C-terminal domain. eIF4A2, a subunit of the eIF4F complex, acts as a protein-synthesis initiation factor and thus plays an important role in the binding of mRNA to the 43S pre … WebAnti-eIF4A2 antibody (ab31218) at 1 µg/ml + Jurkat whole cell lysate at 20 µg Secondary IR Dye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/15000 dilution Performed under reducing conditions. Predicted band …
WebJan 21, 2024 · Although glycolytic primed hESCs rely predominantly on the eukaryotic initiation factor 4E (eIF4E)-mediated cap-dependent pathway for protein translation, naive hESCs with reduced mammalian target of rapamycin complex (mTORC1) activity are more tolerant to eIF4E inhibition, and their bivalent metabolism allows for translating selective …
WebPredominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133). Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with ... chinnville kyWebBackground: EIF4A2, which belongs to the eukaryotic initiation factor 4A family, is a highly conserved gene for one of the protein-synthesis initiation factors involved in the binding of messenger RNA to the ribosome. The role of EIF4A2 in some cancers, eg, breast cancer and melanoma, has been studied. chino jaen pekinWebJun 14, 2024 · Abstract. Eukaryotic initiation factor 4A (eIF4A), the enzymatic core of the eIF4F complex essential for translation initiation, plays a key role in the oncogenic … chino kekkei genkaiWebTarget Information eIF4A2 is a 407 amino acid ATP-dependent RNA helicase belonging to the DEAD box helicase family. It contains one helicase ATP-binding domain and a helicase C-terminal domain. eIF4A2, a subunit of the eIF4F complex, acts as a protein-synthesis initiation factor and thus plays an important role in the binding of mRNA to the 43S pre … chinnville kentuckyWebDec 2, 2024 · eIF4A2 forms an endogenous complex with CNOT1. eIF4A1 and eIF4A2 have been reported to have non-redundant divergent roles in translation regulation [11, 38, … chino mannikarottu mdWebMar 21, 2024 · GeneCards Summary for EIF2AK4 Gene. EIF2AK4 (Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4) is a Protein Coding gene. Diseases associated with … chino villajoyosaWebMar 21, 2024 · EIF4A2 (Eukaryotic Translation Initiation Factor 4A2) is a Protein Coding gene. Diseases associated with EIF4A2 include Fragile X-Associated Tremor/Ataxia Syndrome and Spinocerebellar Ataxia … chinoike male oc