WebObjectives: To determine the clinical outcome and prognostic factors for overall survival in children with recurrent and/or primary refractory Hodgkin disease (HD) after high-dose therapy and autologous hemopoietic stem cell transplantation (AHSCT). The survival outcome of this treatment was compared with conventional salvage therapy without stem … WebMay 1, 2024 · For example, consider a trial with a primary outcome of CR and a secondary outcome of OS with a planned follow-up of 24 months. ... In addition, differences in salvage therapy regimens or allogeneic transplant strategies that may be used following on-study disease progression may alter OS independently of the study drug/therapy.
Relapse of primary central nervous system lymphoma: clinical …
The response rate is the percentage of patients on whom a therapy has some defined effect; for example, the cancer shrinks or disappears after treatment. When used as a clinical endpoint for trials of cancer treatments, this is often called the objective response rate (ORR). The FDA definition of ORR in this context is "the proportion of patients with tumor size reduction of a predefined amount and for a minimum time period." WebMay 31, 2004 · Survival of patients who achieved CR after intensive therapy for primary resistant disease was compared with that of 50 patients who achieved CR after … easy black bear drawings
Clinical outcomes with intensive therapy for patients with primary ...
WebJun 10, 2024 · Inclusion was restricted to studies using an interval of at least 4 weeks between end of neoadjuvant therapy and surgery. The primary outcome was pCR, defined as ypT0N0. Studies that did not report ypTN stage were excluded. Secondary outcomes were ≥ grade 3 toxicity [according to the Common Terminology Criteria for Adverse ... WebFeb 1, 2024 · The primary therapy outcome was defined with contrast-enhanced CT imaging and serum CA125 value at the end of primary therapy according to the standard response evaluation criteria. 5,6 Seven patients had ... (PR) or complete response (CR). During the follow-up, a clinical examination and CA125 measurement were performed every 3 ... WebSep 8, 2016 · Discussion. Figure 4. Next Steps for a Trial in Which the Primary Outcome Is Positive. A significance level of 5% for the primary efficacy outcome is the minimum requirement if a trial is to be ... cuny undergraduate schools