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Primary therapy outcome cr

WebObjectives: To determine the clinical outcome and prognostic factors for overall survival in children with recurrent and/or primary refractory Hodgkin disease (HD) after high-dose therapy and autologous hemopoietic stem cell transplantation (AHSCT). The survival outcome of this treatment was compared with conventional salvage therapy without stem … WebMay 1, 2024 · For example, consider a trial with a primary outcome of CR and a secondary outcome of OS with a planned follow-up of 24 months. ... In addition, differences in salvage therapy regimens or allogeneic transplant strategies that may be used following on-study disease progression may alter OS independently of the study drug/therapy.

Relapse of primary central nervous system lymphoma: clinical …

The response rate is the percentage of patients on whom a therapy has some defined effect; for example, the cancer shrinks or disappears after treatment. When used as a clinical endpoint for trials of cancer treatments, this is often called the objective response rate (ORR). The FDA definition of ORR in this context is "the proportion of patients with tumor size reduction of a predefined amount and for a minimum time period." WebMay 31, 2004 · Survival of patients who achieved CR after intensive therapy for primary resistant disease was compared with that of 50 patients who achieved CR after … easy black bear drawings https://beadtobead.com

Clinical outcomes with intensive therapy for patients with primary ...

WebJun 10, 2024 · Inclusion was restricted to studies using an interval of at least 4 weeks between end of neoadjuvant therapy and surgery. The primary outcome was pCR, defined as ypT0N0. Studies that did not report ypTN stage were excluded. Secondary outcomes were ≥ grade 3 toxicity [according to the Common Terminology Criteria for Adverse ... WebFeb 1, 2024 · The primary therapy outcome was defined with contrast-enhanced CT imaging and serum CA125 value at the end of primary therapy according to the standard response evaluation criteria. 5,6 Seven patients had ... (PR) or complete response (CR). During the follow-up, a clinical examination and CA125 measurement were performed every 3 ... WebSep 8, 2016 · Discussion. Figure 4. Next Steps for a Trial in Which the Primary Outcome Is Positive. A significance level of 5% for the primary efficacy outcome is the minimum requirement if a trial is to be ... cuny undergraduate schools

Pathologic and molecular features correlate with long-term outcome …

Category:Treatment outcome and prognostic factors in PCNSL

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Primary therapy outcome cr

Current and emerging therapies for primary central nervous …

WebMay 13, 2006 · Data on relapsed primary central nervous system lymphoma (PCNSL) are limited. We have evaluated the clinical characteristics and outcome of relapsed PCNSL patients from two German trials. Patients with relapsed disease after primary treatment were studied. Primary therapy consisted of high-dose methotrexate-based chemotherapy … WebPrimary therapy consisted of high-dose methotrexate-based chemotherapy in all patients. Treatment for relapse was not predetermined. After a median follow-up of 22.5 months, …

Primary therapy outcome cr

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WebOct 6, 2024 · PURPOSE Anti-CD19 chimeric antigen receptors (CARs) are artificial fusion proteins that cause CD19-specific T-cell activation. Durability of remissions and incidence of long-term adverse events are critical factors determining the utility of anti-CD19 CAR T-cell therapy, but long-term follow-up of patients treated with anti-CD19 CAR T cells is limited. …

WebSep 8, 2016 · Discussion. Figure 4. Next Steps for a Trial in Which the Primary Outcome Is Positive. A significance level of 5% for the primary efficacy outcome is the minimum … Webadjuvant therapy. Disease-Free Survival (DFS), also known as Relapse-Free Survival (RFS), is often used as a primary endpoint in phase III trials of adjuvant therapy. Progression-Free …

WebThe primary outcome measure is the outcome that an investigator considers to be the most important among the many outcomes that are to be examined in the study. The primary outcome needs to be defined at the time the study is designed. There are 2 reasons for this: it reduces the risk of false-posit … http://www.morimt.net/zixun/78.html

WebApr 14, 2024 · IntroductionMesenchymal stromal cells (MSC) therapy has emerged as a potential treatment option for refractory FCGS. However, there is a lack of long-term data on the use of MSC therapy in cats. This study aimed to evaluate the long-term safety and efficacy of MSC therapy for FCGS and investigate potential factors associated with …

WebDec 15, 2010 · Methods: Adults with ALL who had primary resistance to frontline therapy or who had a disease recurrence after a first complete response (CR) duration <1 year were analyzed. Multivariate analyses for subsequent CR and survival were conducted. Results: Seventy-five of 245 patients (31% cuny unscheduled holidaysWeb(15) The primary endpoint of CR/PR according to NIH criteria without death/relapse/secondary therapy at 6 months was 48.6% for the two-drug and 50% for … easy blackberry cobbler recipe using cake mixWebMar 2, 2024 · Primary refractory which for the purpose of this study is defined as failure to obtain any response (PR or CR) after at least 3 cycles of anthracycline-based therapy or … easy blackberry cobbler recipe bisquickWebNo prognostic factor was associated with PR and, in view of the high frequencies of PR or CR, all patients with primary resistant myeloma should be considered for early intensive … cuny university new yorkWebApr 29, 2024 · Primary central nervous system lymphoma is an invasive malignant lymphoma confined to the central nervous system. Although patients undergoing first-line treatment can achieve complete response, most of them still relapse within two years. Relapsed lymphoma is derived from occult lymphoma cells, and B cell receptor pathway … cuny vehicle policyWebWhen refering to evidence in academic writing, you should always try to reference the primary (original) source. ... This category contains pages relating to outcome measures in cardiopulmonary conditions Pages in category "Cardiopulmonary - Outcome Measures" The following 7 pages are in this category, out of 7 total. 2. cuny vs st. john\\u0027s universityWebMar 12, 2009 · A recent review compared the definitions and clinical criteria used in different studies. 2 It showed widely discrepant criteria used to evaluate patient characteristics, determine responses, and report clinical outcomes. This heterogeneity makes comparison of the results of clinical trials or cohort description uneven and therefore unreliable and … cuny vision benefits